An experiment proposed by Dr. Drago Pettrovich Madnar to use medical cybernetic technology to create a cyborg (cybernetic organism).
Subjects would undergo surgery to replace their bodies with artificial organs; only the head and brain would remain. The rejection response would be less severe than for a full cyborg.
After his death at the hands of Solid Snake, Big Boss became the first test subject. When he was found after his battle with Solid Snake, Big Boss had lost both arms, both legs, his right eye, and his right ear. The Snatcher Project brought him back from the dead.